Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 715713..716210 Replicon chromosome
Accession NZ_CP110404
Organism Shigella sonnei strain S17BD05200

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OKF41_RS03420 Protein ID WP_001173343.1
Coordinates 716037..716210 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag OKF41_RS03415 Protein ID WP_000398619.1
Coordinates 715713..716009 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF41_RS03395 (712444) 712444..713163 - 720 WP_000611285.1 two-component system response regulator DcuR -
OKF41_RS03400 (713160) 713160..714791 - 1632 WP_001216495.1 sensor histidine kinase -
OKF41_RS03405 (714972) 714972..715202 + 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
OKF41_RS03410 (715214) 715214..715486 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
OKF41_RS03415 (715713) 715713..716009 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OKF41_RS03420 (716037) 716037..716210 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OKF41_RS03425 (716329) 716329..717846 - 1518 WP_001295086.1 lysine--tRNA ligase -
OKF41_RS03430 (718083) 718083..719540 - 1458 WP_000856831.1 dipeptide/tripeptide permease DtpC -
OKF41_RS03435 (719599) 719599..719856 - 258 Protein_656 lysine decarboxylase LdcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T263806 WP_001173343.1 NZ_CP110404:716037-716210 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT263806 WP_000398619.1 NZ_CP110404:715713-716009 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References