Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4172725..4173379 Replicon chromosome
Accession NZ_CP110398
Organism Shigella sonnei strain S17BD06357

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag OKF40_RS20955 Protein ID WP_000244777.1
Coordinates 4172725..4173132 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OKF40_RS20960 Protein ID WP_000354046.1
Coordinates 4173113..4173379 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF40_RS20935 (4168682) 4168682..4170415 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
OKF40_RS20940 (4170421) 4170421..4171131 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OKF40_RS20945 (4171156) 4171156..4172052 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OKF40_RS20950 (4172164) 4172164..4172685 + 522 WP_001055874.1 flavodoxin FldB -
OKF40_RS20955 (4172725) 4172725..4173132 - 408 WP_000244777.1 protein YgfX Toxin
OKF40_RS20960 (4173113) 4173113..4173379 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OKF40_RS20965 (4173622) 4173622..4174602 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
OKF40_RS20970 (4174798) 4174798..4175457 - 660 WP_000250274.1 hemolysin III family protein -
OKF40_RS20975 (4175621) 4175621..4175932 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
OKF40_RS20980 (4175977) 4175977..4177410 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
OKF40_RS20985 (4177467) 4177467..4178210 - 744 WP_000951937.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T263802 WP_000244777.1 NZ_CP110398:c4173132-4172725 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT263802 WP_000354046.1 NZ_CP110398:c4173379-4173113 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References