Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1437676..1438294 Replicon chromosome
Accession NZ_CP110398
Organism Shigella sonnei strain S17BD06357

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OKF40_RS06970 Protein ID WP_001291435.1
Coordinates 1437676..1437894 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag OKF40_RS06975 Protein ID WP_000344804.1
Coordinates 1437920..1438294 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF40_RS06935 (1432968) 1432968..1433540 + 573 WP_000779812.1 YbaY family lipoprotein -
OKF40_RS06940 (1433571) 1433571..1433882 - 312 WP_000409911.1 MGMT family protein -
OKF40_RS06950 (1434261) 1434261..1434614 + 354 WP_000878140.1 DUF1428 domain-containing protein -
OKF40_RS06955 (1434656) 1434656..1436204 - 1549 Protein_1342 cyclic-guanylate-specific phosphodiesterase PdeB -
OKF40_RS06960 (1436368) 1436368..1436838 - 471 WP_000136192.1 YlaC family protein -
OKF40_RS06965 (1436954) 1436954..1437505 - 552 WP_000102564.1 maltose O-acetyltransferase -
OKF40_RS06970 (1437676) 1437676..1437894 - 219 WP_001291435.1 HHA domain-containing protein Toxin
OKF40_RS06975 (1437920) 1437920..1438294 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
OKF40_RS06980 (1438840) 1438840..1441989 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
OKF40_RS06985 (1442012) 1442012..1443205 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T263793 WP_001291435.1 NZ_CP110398:c1437894-1437676 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT263793 WP_000344804.1 NZ_CP110398:c1438294-1437920 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References