263792

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1402115..1402952 Replicon chromosome
Accession NZ_CP110398
Organism Shigella sonnei strain S17BD06357

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag OKF40_RS06790 Protein ID WP_000227784.1
Coordinates 1402115..1402657 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag OKF40_RS06795 Protein ID WP_001297137.1
Coordinates 1402641..1402952 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF40_RS06760 (1397179) 1397179..1397670 + 492 WP_001138904.1 nucleotide binding protein YajQ -
OKF40_RS06765 (1397798) 1397798..1399162 - 1365 WP_001000971.1 MFS transporter -
OKF40_RS06770 (1399281) 1399281..1399978 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
OKF40_RS06775 (1400347) 1400347..1400745 + 399 Protein_1307 SEL1-like repeat protein -
OKF40_RS06785 (1401493) 1401493..1402059 + 567 Protein_1309 SEL1-like repeat protein -
OKF40_RS06790 (1402115) 1402115..1402657 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
OKF40_RS06795 (1402641) 1402641..1402952 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
OKF40_RS06800 (1403137) 1403137..1404027 - 891 WP_000971327.1 heme o synthase -
OKF40_RS06805 (1404039) 1404039..1404368 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
OKF40_RS06810 (1404368) 1404368..1404982 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
OKF40_RS06815 (1404972) 1404972..1406963 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
OKF40_RS06820 (1406985) 1406985..1407932 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T263792 WP_000227784.1 NZ_CP110398:c1402657-1402115 [Shigella sonnei]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT263792 WP_001297137.1 NZ_CP110398:c1402952-1402641 [Shigella sonnei]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References