Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 716251..716748 Replicon chromosome
Accession NZ_CP110398
Organism Shigella sonnei strain S17BD06357

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OKF40_RS03420 Protein ID WP_001173343.1
Coordinates 716575..716748 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag OKF40_RS03415 Protein ID WP_000398619.1
Coordinates 716251..716547 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKF40_RS03395 (712982) 712982..713701 - 720 WP_000611285.1 two-component system response regulator DcuR -
OKF40_RS03400 (713698) 713698..715329 - 1632 WP_001216495.1 sensor histidine kinase -
OKF40_RS03405 (715510) 715510..715740 + 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
OKF40_RS03410 (715752) 715752..716024 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
OKF40_RS03415 (716251) 716251..716547 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OKF40_RS03420 (716575) 716575..716748 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OKF40_RS03425 (716867) 716867..718384 - 1518 WP_001295086.1 lysine--tRNA ligase -
OKF40_RS03430 (718621) 718621..720078 - 1458 WP_000856831.1 dipeptide/tripeptide permease DtpC -
OKF40_RS03435 (720137) 720137..720394 - 258 Protein_655 lysine decarboxylase LdcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T263790 WP_001173343.1 NZ_CP110398:716575-716748 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT263790 WP_000398619.1 NZ_CP110398:716251-716547 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References