Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1751143..1753035 Replicon chromosome
Accession NZ_CP110396
Organism Paraburkholderia sp. D15

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LFL96_RS27695 Protein ID WP_281001087.1
Coordinates 1751143..1752138 (+) Length 332 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag LFL96_RS27700 Protein ID WP_281001088.1
Coordinates 1752139..1753035 (+) Length 299 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFL96_RS27665 (LFL96_27685) 1746480..1747553 - 1074 WP_281001083.1 porin -
LFL96_RS27670 (LFL96_27690) 1747993..1748307 + 315 WP_105505421.1 non-heme iron oxygenase ferredoxin subunit -
LFL96_RS27675 (LFL96_27695) 1748309..1748620 + 312 WP_281001084.1 hypothetical protein -
LFL96_RS27680 (LFL96_27700) 1748669..1749781 + 1113 WP_281001085.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
LFL96_RS27685 (LFL96_27705) 1749774..1750541 + 768 WP_281001086.1 SDR family oxidoreductase -
LFL96_RS27690 (LFL96_27710) 1750568..1751095 + 528 WP_281003876.1 cupin domain-containing protein -
LFL96_RS27695 (LFL96_27715) 1751143..1752138 + 996 WP_281001087.1 alpha/beta hydrolase Toxin
LFL96_RS27700 (LFL96_27720) 1752139..1753035 + 897 WP_281001088.1 IclR family transcriptional regulator Antitoxin
LFL96_RS27705 (LFL96_27725) 1753035..1753832 + 798 WP_281001089.1 SDR family oxidoreductase -
LFL96_RS27710 (LFL96_27730) 1753825..1755483 + 1659 WP_281001090.1 thiamine pyrophosphate-binding protein -
LFL96_RS27715 (LFL96_27735) 1755476..1756306 + 831 WP_281001091.1 aspartate dehydrogenase -
LFL96_RS27720 (LFL96_27740) 1756384..1757874 + 1491 WP_281001092.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(57-314)

Antitoxin

Transcription regulator IclR, N-terminal

(34-82)


Sequences

Toxin        


Download         Length: 332 a.a.        Molecular weight: 34274.63 Da        Isoelectric Point: 6.5798

>T263789 WP_281001087.1 NZ_CP110396:1751143-1752138 [Paraburkholderia sp. D15]
MSAVPAVTADPHAEQGTQAGLEARVARFPARQVQLASQRVVSYREADGGSHGDALPLVLLHGIGSGAASWVQQFEALGAT
RRVLAWDAPGYGASTPVEAASPCAGDYAAVLREWLDALGIERCVLLGHSLGAIVAGAFCASSGSSGSAGLAVAQLERVAG
LLLLSPAGGYGAAPAELRDAKRDQRLAMLRDLGPQGLAGQRSGNMVSAHASDEARAWVRWNMSRVIPQGYEQATHLLANA
DLAADLARYRAGFQARVQAQLQARNAAPIAIAVGAEDTITPPAACEHLAQAAGVPLQIVPRAGHAGYIEAPAAYTAIIDT
FCRASDEHRSQ

Download         Length: 996 bp

Antitoxin


Download         Length: 299 a.a.        Molecular weight: 33137.60 Da        Isoelectric Point: 6.3692

>AT263789 WP_281001088.1 NZ_CP110396:1752139-1753035 [Paraburkholderia sp. D15]
MTPDLTNAERDADEDRSETGNDAGSETGYRVPGLERGLRILTEFSPREPVLGAPELSRRLKIPRTTVFRLLQTLESLGFL
ERADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPVIEALRDDTGLTTHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTR
LPAHATTHGQVLMGDMTIDELRKLYPEPELERFTKQTPVTLDDLYERIRDDARRGFAISESSFERGISVVSAPVRNDTGR
IVAVITTTIPRHEIDASLLDSGLIDKVRRAADELSQRLNYRPKSGPKAGSQYMKALGL

Download         Length: 897 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References