Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 2368437..2369082 Replicon chromosome
Accession NZ_CP110395
Organism Paraburkholderia sp. D15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LFL96_RS10140 Protein ID WP_280995127.1
Coordinates 2368657..2369082 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LFL96_RS10135 Protein ID WP_280995126.1
Coordinates 2368437..2368664 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFL96_RS10110 (LFL96_10110) 2363688..2364221 - 534 WP_280995122.1 GNAT family N-acetyltransferase -
LFL96_RS10115 (LFL96_10115) 2364399..2365433 - 1035 WP_280995123.1 DNA polymerase III subunit delta' -
LFL96_RS10120 (LFL96_10120) 2365523..2366143 - 621 WP_280995124.1 dTMP kinase -
LFL96_RS10125 (LFL96_10125) 2366143..2367153 - 1011 WP_281000680.1 endolytic transglycosylase MltG -
LFL96_RS10130 (LFL96_10130) 2367232..2368347 + 1116 WP_280995125.1 folate-binding protein -
LFL96_RS10135 (LFL96_10135) 2368437..2368664 + 228 WP_280995126.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LFL96_RS10140 (LFL96_10140) 2368657..2369082 + 426 WP_280995127.1 PIN domain-containing protein Toxin
LFL96_RS10145 (LFL96_10145) 2369116..2369964 + 849 WP_280995128.1 NRDE family protein -
LFL96_RS10150 (LFL96_10150) 2370051..2371010 - 960 WP_280995129.1 alpha/beta hydrolase -
LFL96_RS10155 (LFL96_10155) 2371053..2372027 - 975 WP_280995130.1 SDR family oxidoreductase -
LFL96_RS10160 (LFL96_10160) 2372139..2373137 - 999 WP_280995131.1 NADP-dependent oxidoreductase -
LFL96_RS10165 (LFL96_10165) 2373307..2373792 - 486 WP_280995132.1 PaaI family thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-36)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15544.77 Da        Isoelectric Point: 4.6155

>T263785 WP_280995127.1 NZ_CP110395:2368657-2369082 [Paraburkholderia sp. D15]
MSEAKAFIDTNVLLYLLSADSEKADQAEATVRAGGRISVQVLNEIANVARRELRMSWADIDEVLSLIRSLCPTDPLTVEI
HVRGKQVAERYGLSVYDSMIVAAALVAGCETLYSEDMQDGLVIDRQVQIRNPFAVHMAPTH

Download         Length: 426 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8485.71 Da        Isoelectric Point: 4.7872

>AT263785 WP_280995126.1 NZ_CP110395:2368437-2368664 [Paraburkholderia sp. D15]
MVVSRWGNSLAIRLPAVVVDALQLQEGDDIEVVLAGARLFELKKKPGREDFLARLREFRGKLPADFTFDRDDANE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References