Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4091332..4092903 Replicon chromosome
Accession NZ_CP110377
Organism Proteus mirabilis strain NYP73

Toxin (Protein)


Gene name hipA Uniprot ID M9PP16
Locus tag ONR65_RS19135 Protein ID WP_004249772.1
Coordinates 4091332..4092645 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag ONR65_RS19140 Protein ID WP_004249771.1
Coordinates 4092646..4092903 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR65_RS19115 (ONR65_19115) 4087521..4088225 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
ONR65_RS19120 (ONR65_19120) 4088262..4089320 - 1059 WP_265028251.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
ONR65_RS19125 (ONR65_19125) 4089352..4090281 - 930 WP_004246518.1 metallophosphoesterase -
ONR65_RS19130 (ONR65_19130) 4090466..4090930 - 465 WP_004249773.1 DUF1097 domain-containing protein -
ONR65_RS19135 (ONR65_19135) 4091332..4092645 - 1314 WP_004249772.1 type II toxin-antitoxin system HipA family toxin Toxin
ONR65_RS19140 (ONR65_19140) 4092646..4092903 - 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
ONR65_RS19145 (ONR65_19145) 4093179..4093808 - 630 WP_001145449.1 hypothetical protein -
ONR65_RS19150 (ONR65_19150) 4093951..4094016 + 66 Protein_3720 EAL domain-containing protein -
ONR65_RS19155 (ONR65_19155) 4094156..4094920 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
ONR65_RS19160 (ONR65_19160) 4095038..4095106 - 69 Protein_3722 EAL domain-containing protein -
ONR65_RS19165 (ONR65_19165) 4095427..4095927 - 501 WP_000376623.1 GNAT family N-acetyltransferase -
ONR65_RS19170 (ONR65_19170) 4096055..4096894 - 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -
ONR65_RS19175 (ONR65_19175) 4096888..4097235 - 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -
ONR65_RS19180 (ONR65_19180) 4097272..4097835 - 564 WP_001027119.1 trimethoprim-resistant dihydrofolate reductase DfrA10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(A) / floR / sul1 / qacE / dfrA10 / aadA2 - 4078049..4129928 51879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49658.73 Da        Isoelectric Point: 6.5023

>T263779 WP_004249772.1 NZ_CP110377:c4092645-4091332 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT263779 WP_004249771.1 NZ_CP110377:c4092903-4092646 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M9PP16

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References