263778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3241557..3242578 Replicon chromosome
Accession NZ_CP110377
Organism Proteus mirabilis strain NYP73

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag ONR65_RS15285 Protein ID WP_004249488.1
Coordinates 3242009..3242578 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag ONR65_RS15280 Protein ID WP_004245528.1
Coordinates 3241557..3242009 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR65_RS15260 (ONR65_15260) 3237344..3237874 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
ONR65_RS15265 (ONR65_15265) 3238190..3239155 + 966 WP_049195511.1 thiamine ABC transporter substrate binding subunit -
ONR65_RS15270 (ONR65_15270) 3239155..3240735 + 1581 WP_004245526.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
ONR65_RS15275 (ONR65_15275) 3240728..3241429 + 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
ONR65_RS15280 (ONR65_15280) 3241557..3242009 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
ONR65_RS15285 (ONR65_15285) 3242009..3242578 + 570 WP_004249488.1 PIN domain-containing protein Toxin
ONR65_RS15290 (ONR65_15290) 3242694..3245048 + 2355 WP_012368319.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21600.10 Da        Isoelectric Point: 7.3470

>T263778 WP_004249488.1 NZ_CP110377:3242009-3242578 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT263778 WP_004245528.1 NZ_CP110377:3241557-3242009 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References