Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1887592..1888391 Replicon chromosome
Accession NZ_CP110377
Organism Proteus mirabilis strain NYP73

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A8E3RD10
Locus tag ONR65_RS09215 Protein ID WP_004247966.1
Coordinates 1887867..1888391 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID B4EVS2
Locus tag ONR65_RS09210 Protein ID WP_004247964.1
Coordinates 1887592..1887870 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR65_RS09185 (ONR65_09185) 1882942..1884024 + 1083 WP_004242680.1 peptide chain release factor 1 -
ONR65_RS09190 (ONR65_09190) 1884024..1884872 + 849 WP_004251398.1 peptide chain release factor N(5)-glutamine methyltransferase -
ONR65_RS09195 (ONR65_09195) 1884850..1885665 + 816 WP_004242688.1 invasion regulator SirB1 -
ONR65_RS09200 (ONR65_09200) 1885723..1886577 + 855 WP_004242689.1 3-deoxy-8-phosphooctulonate synthase -
ONR65_RS09205 (ONR65_09205) 1886585..1887514 + 930 WP_004242691.1 TIGR01212 family radical SAM protein -
ONR65_RS09210 (ONR65_09210) 1887592..1887870 + 279 WP_004247964.1 DUF1778 domain-containing protein Antitoxin
ONR65_RS09215 (ONR65_09215) 1887867..1888391 + 525 WP_004247966.1 hypothetical protein Toxin
ONR65_RS09220 (ONR65_09220) 1888472..1890172 - 1701 WP_004247967.1 C4-dicarboxylic acid transporter DauA -
ONR65_RS09230 (ONR65_09230) 1891136..1892077 + 942 WP_004242695.1 glyoxylate/hydroxypyruvate reductase GhrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-87)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19192.12 Da        Isoelectric Point: 9.3561

>T263777 WP_004247966.1 NZ_CP110377:1887867-1888391 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Download         Length: 525 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10252.82 Da        Isoelectric Point: 5.1369

>AT263777 WP_004247964.1 NZ_CP110377:1887592-1887870 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EVS2

References