Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 10493..11094 Replicon chromosome
Accession NZ_CP110377
Organism Proteus mirabilis strain NYP73

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag ONR65_RS00045 Protein ID WP_049194960.1
Coordinates 10493..10876 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag ONR65_RS00050 Protein ID WP_004246496.1
Coordinates 10873..11094 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR65_RS00025 (ONR65_00025) 6128..7234 - 1107 WP_004249769.1 aspartate-semialdehyde dehydrogenase -
ONR65_RS00030 (ONR65_00030) 7734..8297 + 564 WP_012368640.1 rRNA adenine N-6-methyltransferase family protein -
ONR65_RS00035 (ONR65_00035) 8573..9472 + 900 WP_004246500.1 N-acetylmuramic acid 6-phosphate etherase -
ONR65_RS00040 (ONR65_00040) 9772..10086 - 315 WP_004246498.1 helix-turn-helix transcriptional regulator -
ONR65_RS00045 (ONR65_00045) 10493..10876 - 384 WP_049194960.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
ONR65_RS00050 (ONR65_00050) 10873..11094 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ONR65_RS00055 (ONR65_00055) 11698..11988 + 291 WP_196561058.1 helix-turn-helix transcriptional regulator -
ONR65_RS00060 (ONR65_00060) 11978..13327 + 1350 WP_196561054.1 type II toxin-antitoxin system HipA family toxin -
ONR65_RS00065 (ONR65_00065) 13346..14350 + 1005 WP_191901693.1 SEC-C domain-containing protein -
ONR65_RS00070 (ONR65_00070) 14478..15476 + 999 WP_251106115.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14462.43 Da        Isoelectric Point: 6.6451

>T263775 WP_049194960.1 NZ_CP110377:c10876-10493 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQHFPGVAGMSDPGRAEALIYRVQNRKHDEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT263775 WP_004246496.1 NZ_CP110377:c11094-10873 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References