Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4087210..4088781 Replicon chromosome
Accession NZ_CP110376
Organism Proteus mirabilis strain NYP69

Toxin (Protein)


Gene name hipA Uniprot ID M9PP16
Locus tag ONR68_RS19090 Protein ID WP_004249772.1
Coordinates 4087210..4088523 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag ONR68_RS19095 Protein ID WP_004249771.1
Coordinates 4088524..4088781 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR68_RS19070 (ONR68_19070) 4083399..4084103 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
ONR68_RS19075 (ONR68_19075) 4084140..4085198 - 1059 WP_265028251.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
ONR68_RS19080 (ONR68_19080) 4085230..4086159 - 930 WP_004246518.1 metallophosphoesterase -
ONR68_RS19085 (ONR68_19085) 4086344..4086808 - 465 WP_004249773.1 DUF1097 domain-containing protein -
ONR68_RS19090 (ONR68_19090) 4087210..4088523 - 1314 WP_004249772.1 type II toxin-antitoxin system HipA family toxin Toxin
ONR68_RS19095 (ONR68_19095) 4088524..4088781 - 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
ONR68_RS19100 (ONR68_19100) 4089057..4089686 - 630 WP_001145449.1 hypothetical protein -
ONR68_RS19105 (ONR68_19105) 4089829..4089894 + 66 Protein_3711 EAL domain-containing protein -
ONR68_RS19110 (ONR68_19110) 4090034..4090798 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
ONR68_RS19115 (ONR68_19115) 4090916..4090984 - 69 Protein_3713 EAL domain-containing protein -
ONR68_RS19120 (ONR68_19120) 4091305..4091805 - 501 WP_000376623.1 GNAT family N-acetyltransferase -
ONR68_RS19125 (ONR68_19125) 4091933..4092771 - 839 Protein_3715 sulfonamide-resistant dihydropteroate synthase Sul1 -
ONR68_RS19130 (ONR68_19130) 4092765..4093112 - 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -
ONR68_RS19135 (ONR68_19135) 4093149..4093712 - 564 WP_001027119.1 trimethoprim-resistant dihydrofolate reductase DfrA10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(A) / floR / sul1 / qacE / dfrA10 / aadA2 - 4073927..4125804 51877
- inside Genomic island tet(A) / floR / sul1 / qacE / dfrA10 / aadA2 - 4073612..4125804 52192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49658.73 Da        Isoelectric Point: 6.5023

>T263774 WP_004249772.1 NZ_CP110376:c4088523-4087210 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT263774 WP_004249771.1 NZ_CP110376:c4088781-4088524 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M9PP16

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References