Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3241635..3242656 Replicon chromosome
Accession NZ_CP110376
Organism Proteus mirabilis strain NYP69

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag ONR68_RS15260 Protein ID WP_004249488.1
Coordinates 3242087..3242656 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag ONR68_RS15255 Protein ID WP_004245528.1
Coordinates 3241635..3242087 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR68_RS15235 (ONR68_15235) 3237422..3237952 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
ONR68_RS15240 (ONR68_15240) 3238268..3239233 + 966 WP_049195511.1 thiamine ABC transporter substrate binding subunit -
ONR68_RS15245 (ONR68_15245) 3239233..3240813 + 1581 WP_004245526.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
ONR68_RS15250 (ONR68_15250) 3240806..3241507 + 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
ONR68_RS15255 (ONR68_15255) 3241635..3242087 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
ONR68_RS15260 (ONR68_15260) 3242087..3242656 + 570 WP_004249488.1 PIN domain-containing protein Toxin
ONR68_RS15265 (ONR68_15265) 3242772..3245126 + 2355 WP_012368319.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21600.10 Da        Isoelectric Point: 7.3470

>T263773 WP_004249488.1 NZ_CP110376:3242087-3242656 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT263773 WP_004245528.1 NZ_CP110376:3241635-3242087 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References