Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1887644..1888443 Replicon chromosome
Accession NZ_CP110376
Organism Proteus mirabilis strain NYP69

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A8E3RD10
Locus tag ONR68_RS09190 Protein ID WP_004247966.1
Coordinates 1887919..1888443 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID B4EVS2
Locus tag ONR68_RS09185 Protein ID WP_004247964.1
Coordinates 1887644..1887922 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR68_RS09160 (ONR68_09160) 1882994..1884076 + 1083 WP_004242680.1 peptide chain release factor 1 -
ONR68_RS09165 (ONR68_09165) 1884076..1884924 + 849 WP_004251398.1 peptide chain release factor N(5)-glutamine methyltransferase -
ONR68_RS09170 (ONR68_09170) 1884902..1885717 + 816 WP_004242688.1 invasion regulator SirB1 -
ONR68_RS09175 (ONR68_09175) 1885775..1886629 + 855 WP_004242689.1 3-deoxy-8-phosphooctulonate synthase -
ONR68_RS09180 (ONR68_09180) 1886637..1887566 + 930 WP_004242691.1 TIGR01212 family radical SAM protein -
ONR68_RS09185 (ONR68_09185) 1887644..1887922 + 279 WP_004247964.1 DUF1778 domain-containing protein Antitoxin
ONR68_RS09190 (ONR68_09190) 1887919..1888443 + 525 WP_004247966.1 hypothetical protein Toxin
ONR68_RS09195 (ONR68_09195) 1888524..1890224 - 1701 WP_004247967.1 C4-dicarboxylic acid transporter DauA -
ONR68_RS09205 (ONR68_09205) 1891188..1892129 + 942 WP_004242695.1 glyoxylate/hydroxypyruvate reductase GhrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-87)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19192.12 Da        Isoelectric Point: 9.3561

>T263772 WP_004247966.1 NZ_CP110376:1887919-1888443 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Download         Length: 525 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10252.82 Da        Isoelectric Point: 5.1369

>AT263772 WP_004247964.1 NZ_CP110376:1887644-1887922 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EVS2

References