Detailed information of TA system TA263769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4091021..4092592
• Replicon: chromosome
• Accession: NZ_CP110375
• Organism: Proteus mirabilis strain NYP6

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: M9PP16
• Locus tag: ONR69_RS19090
• Protein ID: WP_004249772.1
• Coordinates: 4091279..4092592 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: ONR69_RS19085
• Protein ID: WP_004249771.1
• Coordinates: 4091021..4091278 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ONR69_RS19045 (ONR69_19045)	4086089..4086652	+	564	WP_001027119.1	trimethoprim-resistant dihydrofolate reductase DfrA10	-
ONR69_RS19050 (ONR69_19050)	4086689..4087036	+	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-
ONR69_RS19055 (ONR69_19055)	4087030..4087869	+	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
ONR69_RS19060 (ONR69_19060)	4087997..4088497	+	501	WP_000376623.1	GNAT family N-acetyltransferase	-
ONR69_RS19065 (ONR69_19065)	4088818..4088886	+	69	Protein_3703	EAL domain-containing protein	-
ONR69_RS19070 (ONR69_19070)	4089004..4089768	+	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
ONR69_RS19075 (ONR69_19075)	4089908..4089973	-	66	Protein_3705	EAL domain-containing protein	-
ONR69_RS19080 (ONR69_19080)	4090116..4090745	+	630	WP_001145449.1	hypothetical protein	-
ONR69_RS19085 (ONR69_19085)	4091021..4091278	+	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
ONR69_RS19090 (ONR69_19090)	4091279..4092592	+	1314	WP_004249772.1	type II toxin-antitoxin system HipA family toxin	Toxin
ONR69_RS19095 (ONR69_19095)	4092994..4093458	+	465	WP_004249773.1	DUF1097 domain-containing protein	-
ONR69_RS19100 (ONR69_19100)	4093643..4094572	+	930	WP_004246518.1	metallophosphoesterase	-
ONR69_RS19105 (ONR69_19105)	4094604..4095662	+	1059	WP_265028251.1	insecticidal delta-endotoxin Cry8Ea1 family protein	-
ONR69_RS19110 (ONR69_19110)	4095699..4096403	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-
ONR69_RS19115 (ONR69_19115)	4096409..4096549	+	141	WP_001044210.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / dfrA10 / floR / tet(A) / fosA3 / blaCTX-M-3 / blaTEM-1B / aadA2	-	4079491..4145180	65689

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49658.73 Da
• Isoelectric Point: 6.5023

>T263769 WP_004249772.1 NZ_CP110375:4091279-4092592 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT263769 WP_004249771.1 NZ_CP110375:4091021-4091278 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

Structures

Toxin

• AlphaFold DB: M9PP16

Antitoxin

• AlphaFold DB: B4F0T9