263769

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4091021..4092592 Replicon chromosome
Accession NZ_CP110375
Organism Proteus mirabilis strain NYP6

Toxin (Protein)


Gene name hipA Uniprot ID M9PP16
Locus tag ONR69_RS19090 Protein ID WP_004249772.1
Coordinates 4091279..4092592 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag ONR69_RS19085 Protein ID WP_004249771.1
Coordinates 4091021..4091278 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR69_RS19045 (ONR69_19045) 4086089..4086652 + 564 WP_001027119.1 trimethoprim-resistant dihydrofolate reductase DfrA10 -
ONR69_RS19050 (ONR69_19050) 4086689..4087036 + 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -
ONR69_RS19055 (ONR69_19055) 4087030..4087869 + 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -
ONR69_RS19060 (ONR69_19060) 4087997..4088497 + 501 WP_000376623.1 GNAT family N-acetyltransferase -
ONR69_RS19065 (ONR69_19065) 4088818..4088886 + 69 Protein_3703 EAL domain-containing protein -
ONR69_RS19070 (ONR69_19070) 4089004..4089768 + 765 WP_001389365.1 IS6-like element IS6100 family transposase -
ONR69_RS19075 (ONR69_19075) 4089908..4089973 - 66 Protein_3705 EAL domain-containing protein -
ONR69_RS19080 (ONR69_19080) 4090116..4090745 + 630 WP_001145449.1 hypothetical protein -
ONR69_RS19085 (ONR69_19085) 4091021..4091278 + 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
ONR69_RS19090 (ONR69_19090) 4091279..4092592 + 1314 WP_004249772.1 type II toxin-antitoxin system HipA family toxin Toxin
ONR69_RS19095 (ONR69_19095) 4092994..4093458 + 465 WP_004249773.1 DUF1097 domain-containing protein -
ONR69_RS19100 (ONR69_19100) 4093643..4094572 + 930 WP_004246518.1 metallophosphoesterase -
ONR69_RS19105 (ONR69_19105) 4094604..4095662 + 1059 WP_265028251.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
ONR69_RS19110 (ONR69_19110) 4095699..4096403 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
ONR69_RS19115 (ONR69_19115) 4096409..4096549 + 141 WP_001044210.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / dfrA10 / floR / tet(A) / fosA3 / blaCTX-M-3 / blaTEM-1B / aadA2 - 4079491..4145180 65689


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49658.73 Da        Isoelectric Point: 6.5023

>T263769 WP_004249772.1 NZ_CP110375:4091279-4092592 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT263769 WP_004249771.1 NZ_CP110375:4091021-4091278 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M9PP16

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References