Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3241505..3242526 Replicon chromosome
Accession NZ_CP110375
Organism Proteus mirabilis strain NYP6

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag ONR69_RS15220 Protein ID WP_004249488.1
Coordinates 3241957..3242526 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag ONR69_RS15215 Protein ID WP_004245528.1
Coordinates 3241505..3241957 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR69_RS15195 (ONR69_15195) 3237292..3237822 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
ONR69_RS15200 (ONR69_15200) 3238138..3239103 + 966 WP_049195511.1 thiamine ABC transporter substrate binding subunit -
ONR69_RS15205 (ONR69_15205) 3239103..3240683 + 1581 WP_004245526.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
ONR69_RS15210 (ONR69_15210) 3240676..3241377 + 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
ONR69_RS15215 (ONR69_15215) 3241505..3241957 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
ONR69_RS15220 (ONR69_15220) 3241957..3242526 + 570 WP_004249488.1 PIN domain-containing protein Toxin
ONR69_RS15225 (ONR69_15225) 3242642..3244996 + 2355 WP_012368319.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21600.10 Da        Isoelectric Point: 7.3470

>T263768 WP_004249488.1 NZ_CP110375:3241957-3242526 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT263768 WP_004245528.1 NZ_CP110375:3241505-3241957 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References