Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1887505..1888304 Replicon chromosome
Accession NZ_CP110375
Organism Proteus mirabilis strain NYP6

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A8E3RD10
Locus tag ONR69_RS09155 Protein ID WP_004247966.1
Coordinates 1887780..1888304 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID B4EVS2
Locus tag ONR69_RS09150 Protein ID WP_004247964.1
Coordinates 1887505..1887783 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR69_RS09125 (ONR69_09125) 1882855..1883937 + 1083 WP_004242680.1 peptide chain release factor 1 -
ONR69_RS09130 (ONR69_09130) 1883937..1884785 + 849 WP_004251398.1 peptide chain release factor N(5)-glutamine methyltransferase -
ONR69_RS09135 (ONR69_09135) 1884763..1885578 + 816 WP_004242688.1 invasion regulator SirB1 -
ONR69_RS09140 (ONR69_09140) 1885636..1886490 + 855 WP_004242689.1 3-deoxy-8-phosphooctulonate synthase -
ONR69_RS09145 (ONR69_09145) 1886498..1887427 + 930 WP_004242691.1 TIGR01212 family radical SAM protein -
ONR69_RS09150 (ONR69_09150) 1887505..1887783 + 279 WP_004247964.1 DUF1778 domain-containing protein Antitoxin
ONR69_RS09155 (ONR69_09155) 1887780..1888304 + 525 WP_004247966.1 hypothetical protein Toxin
ONR69_RS09160 (ONR69_09160) 1888385..1890085 - 1701 WP_004247967.1 C4-dicarboxylic acid transporter DauA -
ONR69_RS09170 (ONR69_09170) 1891049..1891990 + 942 WP_004242695.1 glyoxylate/hydroxypyruvate reductase GhrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-87)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19192.12 Da        Isoelectric Point: 9.3561

>T263767 WP_004247966.1 NZ_CP110375:1887780-1888304 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Download         Length: 525 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10252.82 Da        Isoelectric Point: 5.1369

>AT263767 WP_004247964.1 NZ_CP110375:1887505-1887783 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EVS2

References