Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4047637..4048248 Replicon chromosome
Accession NZ_CP110373
Organism Proteus mirabilis strain CZP26

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ONR66_RS18775 Protein ID WP_237075908.1
Coordinates 4047637..4047990 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag ONR66_RS18780 Protein ID WP_004249771.1
Coordinates 4047991..4048248 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR66_RS18755 (ONR66_18755) 4042870..4043673 + 804 WP_049220158.1 energy transducer TonB -
ONR66_RS18760 (ONR66_18760) 4043727..4045688 - 1962 WP_012368635.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
ONR66_RS18765 (ONR66_18765) 4045720..4046649 - 930 WP_004246518.1 metallophosphoesterase -
ONR66_RS18770 (ONR66_18770) 4046834..4047298 - 465 WP_012368636.1 DUF1097 domain-containing protein -
ONR66_RS18775 (ONR66_18775) 4047637..4047990 - 354 WP_237075908.1 HipA N-terminal domain-containing protein Toxin
ONR66_RS18780 (ONR66_18780) 4047991..4048248 - 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
ONR66_RS18785 (ONR66_18785) 4048397..4049761 - 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
ONR66_RS18790 (ONR66_18790) 4049899..4051539 - 1641 WP_004246512.1 membrane protein insertase YidC -
ONR66_RS18795 (ONR66_18795) 4051542..4051802 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
ONR66_RS18800 (ONR66_18800) 4051766..4052125 - 360 WP_004246510.1 ribonuclease P protein component -
ONR66_RS18805 (ONR66_18805) 4052143..4052286 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13114.70 Da        Isoelectric Point: 4.5238

>T263764 WP_237075908.1 NZ_CP110373:c4047990-4047637 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIE

Download         Length: 354 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT263764 WP_004249771.1 NZ_CP110373:c4048248-4047991 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References