Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3739484..3740133 Replicon chromosome
Accession NZ_CP110373
Organism Proteus mirabilis strain CZP26

Toxin (Protein)


Gene name vagD Uniprot ID B4EZB9
Locus tag ONR66_RS17390 Protein ID WP_012368534.1
Coordinates 3739484..3739903 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag ONR66_RS17395 Protein ID WP_012368535.1
Coordinates 3739900..3740133 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR66_RS17360 (ONR66_17360) 3735490..3736404 - 915 WP_004249085.1 fatty acid biosynthesis protein FabY -
ONR66_RS17365 (ONR66_17365) 3736428..3736865 - 438 WP_004246810.1 D-aminoacyl-tRNA deacylase -
ONR66_RS17370 (ONR66_17370) 3736946..3737563 - 618 WP_020946398.1 glucose-1-phosphatase -
ONR66_RS17375 (ONR66_17375) 3737905..3738213 - 309 WP_004246808.1 helix-turn-helix transcriptional regulator -
ONR66_RS17380 (ONR66_17380) 3738542..3738958 - 417 WP_049196823.1 hypothetical protein -
ONR66_RS17385 (ONR66_17385) 3738936..3739259 - 324 WP_012368533.1 hypothetical protein -
ONR66_RS17390 (ONR66_17390) 3739484..3739903 - 420 WP_012368534.1 type II toxin-antitoxin system VapC family toxin Toxin
ONR66_RS17395 (ONR66_17395) 3739900..3740133 - 234 WP_012368535.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ONR66_RS17400 (ONR66_17400) 3740401..3740553 + 153 WP_167552341.1 hypothetical protein -
ONR66_RS17405 (ONR66_17405) 3740884..3742719 - 1836 WP_004246802.1 ribosome-dependent GTPase TypA -
ONR66_RS17410 (ONR66_17410) 3743079..3744488 + 1410 WP_004246801.1 glutamate--ammonia ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15371.88 Da        Isoelectric Point: 7.7288

>T263763 WP_012368534.1 NZ_CP110373:c3739903-3739484 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT263763 WP_012368535.1 NZ_CP110373:c3740133-3739900 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZB9

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References