Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3718056..3718755 Replicon chromosome
Accession NZ_CP110373
Organism Proteus mirabilis strain CZP26

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ONR66_RS17275 Protein ID WP_163806902.1
Coordinates 3718056..3718442 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag ONR66_RS17280 Protein ID WP_004246828.1
Coordinates 3718435..3718755 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR66_RS17260 (ONR66_17260) 3714075..3714656 - 582 WP_020946389.1 DNA-3-methyladenine glycosylase I -
ONR66_RS17265 (ONR66_17265) 3714907..3715812 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
ONR66_RS17270 (ONR66_17270) 3715822..3717894 + 2073 WP_041701373.1 glycine--tRNA ligase subunit beta -
ONR66_RS17275 (ONR66_17275) 3718056..3718442 + 387 WP_163806902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ONR66_RS17280 (ONR66_17280) 3718435..3718755 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
ONR66_RS17285 (ONR66_17285) 3718804..3719238 - 435 WP_036972158.1 hypothetical protein -
ONR66_RS17290 (ONR66_17290) 3719231..3720115 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
ONR66_RS17295 (ONR66_17295) 3720333..3721619 - 1287 WP_049220287.1 DUF3748 domain-containing protein -
ONR66_RS17300 (ONR66_17300) 3721756..3722373 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
ONR66_RS17305 (ONR66_17305) 3722675..3723298 + 624 WP_004246821.1 guanylate kinase -
ONR66_RS17310 (ONR66_17310) 3723353..3723628 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14322.69 Da        Isoelectric Point: 10.0642

>T263762 WP_163806902.1 NZ_CP110373:3718056-3718442 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNVNQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT263762 WP_004246828.1 NZ_CP110373:3718435-3718755 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References