Detailed information of TA system TA263760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3320323..3322045
• Replicon: chromosome
• Accession: NZ_CP110373
• Organism: Proteus mirabilis strain CZP26

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: ONR66_RS15520
• Protein ID: WP_211868028.1
• Coordinates: 3320323..3321261 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: ONR66_RS15525
• Protein ID: WP_223293371.1
• Coordinates: 3321254..3322045 (-)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ONR66_RS15500 (ONR66_15500)	3316264..3316776	-	513	WP_223293369.1	S26 family signal peptidase	-
ONR66_RS15505 (ONR66_15505)	3316760..3317107	-	348	WP_004249366.1	hypothetical protein	-
ONR66_RS15510 (ONR66_15510)	3317100..3319499	-	2400	WP_223293370.1	type IV secretion system protein TraC	-
ONR66_RS15515 (ONR66_15515)	3319499..3320191	-	693	WP_001228924.1	DsbC family protein	-
ONR66_RS15520 (ONR66_15520)	3320323..3321261	-	939	WP_211868028.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ONR66_RS15525 (ONR66_15525)	3321254..3322045	-	792	WP_223293371.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ONR66_RS15530 (ONR66_15530)	3322266..3322652	-	387	WP_032469918.1	TraA family conjugative transfer protein	-
ONR66_RS15535 (ONR66_15535)	3322649..3323221	-	573	WP_148039504.1	type IV conjugative transfer system lipoprotein TraV	-
ONR66_RS15540 (ONR66_15540)	3323296..3324585	-	1290	WP_159262611.1	TraB/VirB10 family protein	-
ONR66_RS15545 (ONR66_15545)	3324588..3325484	-	897	WP_159262630.1	type-F conjugative transfer system secretin TraK	-
ONR66_RS15550 (ONR66_15550)	3325468..3326094	-	627	WP_159262613.1	TraE/TraK family type IV conjugative transfer system protein	-
ONR66_RS15555 (ONR66_15555)	3326091..3326372	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
ONR66_RS15560 (ONR66_15560)	3326553..3326876	+	324	WP_001896384.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J) / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-VIa / floR / erm(42)	-	3228820..3417947	189127

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35578.85 Da
• Isoelectric Point: 4.9081

>T263760 WP_211868028.1 NZ_CP110373:c3321261-3320323 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQTKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30195.54 Da
• Isoelectric Point: 9.3573

>AT263760 WP_223293371.1 NZ_CP110373:c3322045-3321254 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYTQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRIRVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIELGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp