Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3168164..3169185 | Replicon | chromosome |
| Accession | NZ_CP110373 | ||
| Organism | Proteus mirabilis strain CZP26 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | ONR66_RS14850 | Protein ID | WP_143474977.1 |
| Coordinates | 3168616..3169185 (+) | Length | 190 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | ONR66_RS14845 | Protein ID | WP_163806848.1 |
| Coordinates | 3168164..3168616 (+) | Length | 151 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ONR66_RS14825 (ONR66_14825) | 3163950..3164480 | - | 531 | WP_004245524.1 | RNA pyrophosphohydrolase | - |
| ONR66_RS14830 (ONR66_14830) | 3164797..3165762 | + | 966 | WP_064506286.1 | thiamine ABC transporter substrate binding subunit | - |
| ONR66_RS14835 (ONR66_14835) | 3165762..3167342 | + | 1581 | WP_004245526.1 | thiamine/thiamine pyrophosphate ABC transporter permease ThiP | - |
| ONR66_RS14840 (ONR66_14840) | 3167335..3168036 | + | 702 | WP_004245527.1 | thiamine ABC transporter ATP-binding protein ThiQ | - |
| ONR66_RS14845 (ONR66_14845) | 3168164..3168616 | + | 453 | WP_163806848.1 | helix-turn-helix domain-containing protein | Antitoxin |
| ONR66_RS14850 (ONR66_14850) | 3168616..3169185 | + | 570 | WP_143474977.1 | PIN domain-containing protein | Toxin |
| ONR66_RS14855 (ONR66_14855) | 3169301..3171655 | + | 2355 | WP_143474976.1 | DNA polymerase II | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 190 a.a. Molecular weight: 21618.11 Da Isoelectric Point: 7.3470
>T263759 WP_143474977.1 NZ_CP110373:3168616-3169185 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYES
LICGLKLPDPNDRHVLVAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYES
LICGLKLPDPNDRHVLVAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL
Download Length: 570 bp
Antitoxin
Download Length: 151 a.a. Molecular weight: 16714.18 Da Isoelectric Point: 5.7723
>AT263759 WP_163806848.1 NZ_CP110373:3168164-3168616 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSLIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIIAYKNELEQKRLDALAELSQLDQEMDMGY
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSLIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIIAYKNELEQKRLDALAELSQLDQEMDMGY
Download Length: 453 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|