Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 81641..83239 Replicon chromosome
Accession NZ_CP110373
Organism Proteus mirabilis strain CZP26

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ONR66_RS00410 Protein ID WP_020946556.1
Coordinates 81641..82984 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ONR66_RS00415 Protein ID WP_041701484.1
Coordinates 82988..83239 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR66_RS00390 (ONR66_00390) 77258..78442 + 1185 WP_004246423.1 multidrug efflux MFS transporter EmrD -
ONR66_RS00395 (ONR66_00395) 78552..80084 - 1533 WP_004246422.1 glycerol kinase GlpK -
ONR66_RS00400 (ONR66_00400) 80127..80942 - 816 WP_004246421.1 MIP/aquaporin family protein -
ONR66_RS00405 (ONR66_00405) 81239..81481 + 243 WP_012368679.1 cell division protein ZapB -
ONR66_RS00410 (ONR66_00410) 81641..82984 - 1344 WP_020946556.1 type II toxin-antitoxin system HipA family toxin Toxin
ONR66_RS00415 (ONR66_00415) 82988..83239 - 252 WP_041701484.1 helix-turn-helix domain-containing protein Antitoxin
ONR66_RS00420 (ONR66_00420) 83480..83745 + 266 Protein_83 IS4 family transposase -
ONR66_RS00425 (ONR66_00425) 83815..84333 - 519 WP_004246419.1 ribonuclease E activity regulator RraA -
ONR66_RS00430 (ONR66_00430) 84442..85359 - 918 WP_020946557.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
ONR66_RS00435 (ONR66_00435) 85458..86798 - 1341 WP_004246417.1 HslU--HslV peptidase ATPase subunit -
ONR66_RS00440 (ONR66_00440) 86811..87341 - 531 WP_004246416.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 49801.23 Da        Isoelectric Point: 5.3203

>T263758 WP_020946556.1 NZ_CP110373:c82984-81641 [Proteus mirabilis]
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMIDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRWSSGTSSQNMMVSN

Download         Length: 1344 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9390.83 Da        Isoelectric Point: 9.8955

>AT263758 WP_041701484.1 NZ_CP110373:c83239-82988 [Proteus mirabilis]
MKITTPSMLAAAIHDLRKQSKLTQAQTAEQVGLRQATVSEFENNPESTKLETLFKILASLELELHVVKRGKNLSEGKVWN
KEW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References