Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3811750..3812449 Replicon chromosome
Accession NZ_CP110372
Organism Proteus mirabilis strain CZP44

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag ONR64_RS17505 Protein ID WP_004249093.1
Coordinates 3812063..3812449 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag ONR64_RS17500 Protein ID WP_004246828.1
Coordinates 3811750..3812070 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR64_RS17470 (ONR64_17470) 3806878..3807153 - 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -
ONR64_RS17475 (ONR64_17475) 3807208..3807831 - 624 WP_004246821.1 guanylate kinase -
ONR64_RS17480 (ONR64_17480) 3808133..3808750 - 618 WP_004246822.1 trimeric intracellular cation channel family protein -
ONR64_RS17485 (ONR64_17485) 3808887..3810173 + 1287 WP_049256516.1 DUF3748 domain-containing protein -
ONR64_RS17490 (ONR64_17490) 3810390..3811274 + 885 WP_004249091.1 endonuclease/exonuclease/phosphatase family protein -
ONR64_RS17495 (ONR64_17495) 3811267..3811701 + 435 WP_004246827.1 hypothetical protein -
ONR64_RS17500 (ONR64_17500) 3811750..3812070 - 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
ONR64_RS17505 (ONR64_17505) 3812063..3812449 - 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ONR64_RS17510 (ONR64_17510) 3812611..3814683 - 2073 WP_004246830.1 glycine--tRNA ligase subunit beta -
ONR64_RS17515 (ONR64_17515) 3814693..3815598 - 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
ONR64_RS17520 (ONR64_17520) 3815849..3816430 + 582 WP_004246833.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T263756 WP_004249093.1 NZ_CP110372:c3812449-3812063 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT263756 WP_004246828.1 NZ_CP110372:c3812070-3811750 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References