Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3449560..3451131 Replicon chromosome
Accession NZ_CP110372
Organism Proteus mirabilis strain CZP44

Toxin (Protein)


Gene name hipA Uniprot ID M9PP16
Locus tag ONR64_RS15850 Protein ID WP_004249772.1
Coordinates 3449818..3451131 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag ONR64_RS15845 Protein ID WP_004249771.1
Coordinates 3449560..3449817 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR64_RS15820 (ONR64_15820) 3445522..3445665 + 144 WP_004246509.1 50S ribosomal protein L34 -
ONR64_RS15825 (ONR64_15825) 3445683..3446042 + 360 WP_004246510.1 ribonuclease P protein component -
ONR64_RS15830 (ONR64_15830) 3446006..3446266 + 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
ONR64_RS15835 (ONR64_15835) 3446269..3447909 + 1641 WP_004246512.1 membrane protein insertase YidC -
ONR64_RS15840 (ONR64_15840) 3448047..3449411 + 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
ONR64_RS15845 (ONR64_15845) 3449560..3449817 + 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
ONR64_RS15850 (ONR64_15850) 3449818..3451131 + 1314 WP_004249772.1 type II toxin-antitoxin system HipA family toxin Toxin
ONR64_RS15855 (ONR64_15855) 3451534..3451998 + 465 WP_004249773.1 DUF1097 domain-containing protein -
ONR64_RS15860 (ONR64_15860) 3452183..3453112 + 930 WP_004246518.1 metallophosphoesterase -
ONR64_RS15865 (ONR64_15865) 3453144..3455105 + 1962 WP_036919429.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
ONR64_RS15870 (ONR64_15870) 3455159..3455962 - 804 WP_004249775.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49658.73 Da        Isoelectric Point: 6.5023

>T263755 WP_004249772.1 NZ_CP110372:3449818-3451131 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT263755 WP_004249771.1 NZ_CP110372:3449560-3449817 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M9PP16

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References