Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3433709..3434310 Replicon chromosome
Accession NZ_CP110372
Organism Proteus mirabilis strain CZP44

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag ONR64_RS15775 Protein ID WP_004246497.1
Coordinates 3433927..3434310 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag ONR64_RS15770 Protein ID WP_004246496.1
Coordinates 3433709..3433930 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR64_RS15745 (ONR64_15745) 3429494..3429952 + 459 WP_004246490.1 dUTP diphosphatase -
ONR64_RS15750 (ONR64_15750) 3430072..3430677 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
ONR64_RS15755 (ONR64_15755) 3430996..3431640 - 645 WP_004246493.1 orotate phosphoribosyltransferase -
ONR64_RS15760 (ONR64_15760) 3431722..3432438 - 717 WP_004249760.1 ribonuclease PH -
ONR64_RS15765 (ONR64_15765) 3432565..3433428 + 864 WP_004249947.1 YicC/YloC family endoribonuclease -
ONR64_RS15770 (ONR64_15770) 3433709..3433930 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ONR64_RS15775 (ONR64_15775) 3433927..3434310 + 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
ONR64_RS15780 (ONR64_15780) 3434718..3435032 + 315 WP_004246498.1 helix-turn-helix transcriptional regulator -
ONR64_RS15785 (ONR64_15785) 3435332..3436231 - 900 WP_004246500.1 N-acetylmuramic acid 6-phosphate etherase -
ONR64_RS15790 (ONR64_15790) 3436507..3437070 - 564 WP_012368640.1 rRNA adenine N-6-methyltransferase family protein -
ONR64_RS15795 (ONR64_15795) 3437570..3438676 + 1107 WP_060555875.1 aspartate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T263754 WP_004246497.1 NZ_CP110372:3433927-3434310 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT263754 WP_004246496.1 NZ_CP110372:3433709-3433930 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References