263752

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 267767..268788 Replicon chromosome
Accession NZ_CP110372
Organism Proteus mirabilis strain CZP44

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A8E4FRK4
Locus tag ONR64_RS01175 Protein ID WP_017827532.1
Coordinates 267767..268336 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag ONR64_RS01180 Protein ID WP_004245528.1
Coordinates 268336..268788 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR64_RS01170 (ONR64_01170) 265297..267651 - 2355 WP_107337099.1 DNA polymerase II -
ONR64_RS01175 (ONR64_01175) 267767..268336 - 570 WP_017827532.1 PIN domain-containing protein Toxin
ONR64_RS01180 (ONR64_01180) 268336..268788 - 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
ONR64_RS01185 (ONR64_01185) 268916..269617 - 702 WP_265071878.1 thiamine ABC transporter ATP-binding protein ThiQ -
ONR64_RS01190 (ONR64_01190) 269610..271190 - 1581 WP_104731821.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
ONR64_RS01195 (ONR64_01195) 271190..272155 - 966 WP_049195511.1 thiamine ABC transporter substrate binding subunit -
ONR64_RS01200 (ONR64_01200) 272472..273002 + 531 WP_004245524.1 RNA pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21601.08 Da        Isoelectric Point: 7.0180

>T263752 WP_017827532.1 NZ_CP110372:c268336-267767 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKDPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT263752 WP_004245528.1 NZ_CP110372:c268788-268336 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References