Detailed information of TA system TA263751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 115915..117637
• Replicon: chromosome
• Accession: NZ_CP110372
• Organism: Proteus mirabilis strain CZP44

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: ONR64_RS00510
• Protein ID: WP_211868028.1
• Coordinates: 116699..117637 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: ONR64_RS00505
• Protein ID: WP_223293371.1
• Coordinates: 115915..116706 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ONR64_RS00470 (ONR64_00470)	111084..111407	-	324	WP_001896384.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ONR64_RS00475 (ONR64_00475)	111588..111869	+	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
ONR64_RS00480 (ONR64_00480)	111866..112492	+	627	WP_159262613.1	TraE/TraK family type IV conjugative transfer system protein	-
ONR64_RS00485 (ONR64_00485)	112476..113372	+	897	WP_159262630.1	type-F conjugative transfer system secretin TraK	-
ONR64_RS00490 (ONR64_00490)	113375..114664	+	1290	WP_159262611.1	TraB/VirB10 family protein	-
ONR64_RS00495 (ONR64_00495)	114739..115311	+	573	WP_148039504.1	type IV conjugative transfer system lipoprotein TraV	-
ONR64_RS00500 (ONR64_00500)	115308..115694	+	387	WP_032469918.1	TraA family conjugative transfer protein	-
ONR64_RS00505 (ONR64_00505)	115915..116706	+	792	WP_223293371.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ONR64_RS00510 (ONR64_00510)	116699..117637	+	939	WP_211868028.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ONR64_RS00515 (ONR64_00515)	117769..118461	+	693	WP_001228924.1	DsbC family protein	-
ONR64_RS00520 (ONR64_00520)	118461..120860	+	2400	WP_223293370.1	type IV secretion system protein TraC	-
ONR64_RS00525 (ONR64_00525)	120853..121200	+	348	WP_004249366.1	hypothetical protein	-
ONR64_RS00530 (ONR64_00530)	121184..121696	+	513	WP_223293369.1	S26 family signal peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J)	htpB	1294..204974	203680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35578.85 Da
• Isoelectric Point: 4.9081

>T263751 WP_211868028.1 NZ_CP110372:116699-117637 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQTKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30195.54 Da
• Isoelectric Point: 9.3573

>AT263751 WP_223293371.1 NZ_CP110372:115915-116706 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYTQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRIRVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIELGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp