Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 706914..708636 | Replicon | chromosome |
| Accession | NZ_CP110371 | ||
| Organism | Proteus mirabilis strain CZP17 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | ONR70_RS03115 | Protein ID | WP_170355928.1 |
| Coordinates | 707698..708636 (+) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | ONR70_RS03110 | Protein ID | WP_170355935.1 |
| Coordinates | 706914..707690 (+) | Length | 259 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ONR70_RS03080 (ONR70_03080) | 702588..702869 | + | 282 | WP_000433891.1 | type IV conjugative transfer system protein TraL | - |
| ONR70_RS03085 (ONR70_03085) | 702866..703492 | + | 627 | WP_000667170.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| ONR70_RS03090 (ONR70_03090) | 703476..704372 | + | 897 | WP_170355937.1 | type-F conjugative transfer system secretin TraK | - |
| ONR70_RS03095 (ONR70_03095) | 704375..705664 | + | 1290 | WP_170383165.1 | TraB/VirB10 family protein | - |
| ONR70_RS03100 (ONR70_03100) | 705739..706311 | + | 573 | WP_001944091.1 | type IV conjugative transfer system lipoprotein TraV | - |
| ONR70_RS03105 (ONR70_03105) | 706308..706694 | + | 387 | WP_000180225.1 | TraA family conjugative transfer protein | - |
| ONR70_RS03110 (ONR70_03110) | 706914..707690 | + | 777 | WP_170355935.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| ONR70_RS03115 (ONR70_03115) | 707698..708636 | + | 939 | WP_170355928.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| ONR70_RS03120 (ONR70_03120) | 708768..709460 | + | 693 | WP_001228924.1 | DsbC family protein | - |
| ONR70_RS03125 (ONR70_03125) | 709460..711859 | + | 2400 | WP_170355926.1 | type IV secretion system protein TraC | - |
| ONR70_RS03130 (ONR70_03130) | 711852..712199 | + | 348 | WP_156734078.1 | plasmid-related protein | - |
| ONR70_RS03135 (ONR70_03135) | 712183..712695 | + | 513 | WP_170355924.1 | S26 family signal peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | floR / tet(A) / aph(6)-Id / aph(3')-VIa / aph(3'')-Ib / sul2 / tet(J) | htpB | 562337..802679 | 240342 | |
| - | inside | Integron | aac(6')-Ib-cr / blaOXA-1 / ARR-3 / qacE / aadA17 / sul1 / catB3 | rpe / hcp / tufA / htpB / rfaE / lpxC / rtxH / algU / katA / rcsB / flhD / flhC / motA / cheA / cheW / cheB / cheY / cheZ / flhA / flgB / flgC / flgG / flgH / flgI / fliQ / fliP / fliN / fliM / fliI / fliG / fliA / gtrB / galU / sodB / hcp / kdsA / flmH / ompA / hcp / tssB / AHA_1833 / nueA / msbA / allD / gnd / luxS / gmhA/lpcA / acrB / wbtL / tufA / ugd / rfaD | 3..4134675 | 4134672 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35664.00 Da Isoelectric Point: 5.2653
>T263748 WP_170355928.1 NZ_CP110371:707698-708636 [Proteus mirabilis]
MDKYSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYRNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKYSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYRNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
Antitoxin
Download Length: 259 a.a. Molecular weight: 29578.97 Da Isoelectric Point: 9.3775
>AT263748 WP_170355935.1 NZ_CP110371:706914-707690 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKRG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKRG
Download Length: 777 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|