Detailed information of TA system TA263746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4699..6270
• Replicon: chromosome
• Accession: NZ_CP110371
• Organism: Proteus mirabilis strain CZP17

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: ONR70_RS00055
• Protein ID: WP_104731898.1
• Coordinates: 4957..6270 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: ONR70_RS00050
• Protein ID: WP_004249771.1
• Coordinates: 4699..4956 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ONR70_RS00010 (ONR70_00010)	6..250	+	245	Protein_1	DUF4111 domain-containing protein	-
ONR70_RS00015 (ONR70_00015)	367..714	+	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-
ONR70_RS00020 (ONR70_00020)	708..1547	+	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
ONR70_RS00025 (ONR70_00025)	1675..2175	+	501	WP_000376623.1	GNAT family N-acetyltransferase	-
ONR70_RS00030 (ONR70_00030)	2496..2564	+	69	Protein_5	EAL domain-containing protein	-
ONR70_RS00035 (ONR70_00035)	2682..3446	+	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
ONR70_RS00040 (ONR70_00040)	3586..3651	-	66	Protein_7	EAL domain-containing protein	-
ONR70_RS00045 (ONR70_00045)	3794..4423	+	630	WP_001145449.1	hypothetical protein	-
ONR70_RS00050 (ONR70_00050)	4699..4956	+	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
ONR70_RS00055 (ONR70_00055)	4957..6270	+	1314	WP_104731898.1	type II toxin-antitoxin system HipA family toxin	Toxin
ONR70_RS00060 (ONR70_00060)	6672..7136	+	465	WP_004246516.1	DUF1097 domain-containing protein	-
ONR70_RS00065 (ONR70_00065)	7321..7866	+	546	WP_265028159.1	hypothetical protein	-
ONR70_RS00075 (ONR70_00075)	9077..9511	+	435	WP_265028160.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	aac(6')-Ib-cr / blaOXA-1 / ARR-3 / qacE / aadA17 / sul1 / catB3	rpe / hcp / tufA / htpB / rfaE / lpxC / rtxH / algU / katA / rcsB / flhD / flhC / motA / cheA / cheW / cheB / cheY / cheZ / flhA / flgB / flgC / flgG / flgH / flgI / fliQ / fliP / fliN / fliM / fliI / fliG / fliA / gtrB / galU / sodB / hcp / kdsA / flmH / ompA / hcp / tssB / AHA_1833 / nueA / msbA / allD / gnd / luxS / gmhA/lpcA / acrB / wbtL / tufA / ugd / rfaD	3..4134675	4134672

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49697.85 Da
• Isoelectric Point: 6.6588

>T263746 WP_104731898.1 NZ_CP110371:4957-6270 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDVKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT263746 WP_004249771.1 NZ_CP110371:4699-4956 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

Structures

Antitoxin

• AlphaFold DB: B4F0T9