Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4973121..4974802 Replicon chromosome
Accession NZ_CP110369
Organism Klebsiella pneumoniae isolate KP7626

Toxin (Protein)


Gene name mosT Uniprot ID J2XCI1
Locus tag OM094_RS24345 Protein ID WP_004146663.1
Coordinates 4973121..4974038 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag OM094_RS24350 Protein ID WP_032418188.1
Coordinates 4974044..4974802 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM094_RS24325 (4968427) 4968427..4969947 + 1521 WP_032418186.1 sugar ABC transporter ATP-binding protein -
OM094_RS24330 (4969944) 4969944..4970942 + 999 WP_002885172.1 ribose ABC transporter permease -
OM094_RS24335 (4970973) 4970973..4971914 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OM094_RS24340 (4971989) 4971989..4972996 + 1008 WP_032418187.1 carbohydrate kinase family protein -
OM094_RS24345 (4973121) 4973121..4974038 - 918 WP_004146663.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OM094_RS24350 (4974044) 4974044..4974802 - 759 WP_032418188.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OM094_RS24355 (4974888) 4974888..4975616 - 729 WP_004210017.1 response regulator transcription factor -
OM094_RS24360 (4975889) 4975889..4978036 + 2148 WP_077598926.1 formate dehydrogenase subunit alpha -
OM094_RS24365 (4978033) 4978033..4978176 - 144 WP_022631365.1 hypothetical protein -
OM094_RS24370 (4978382) 4978382..4979068 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34659.10 Da        Isoelectric Point: 5.4707

>T263743 WP_004146663.1 NZ_CP110369:c4974038-4973121 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28620.99 Da        Isoelectric Point: 10.0001

>AT263743 WP_032418188.1 NZ_CP110369:c4974802-4974044 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPETLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB J2XCI1


Antitoxin

Source ID Structure

References