Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4630880..4631690 Replicon chromosome
Accession NZ_CP110369
Organism Klebsiella pneumoniae isolate KP7626

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag OM094_RS22665 Protein ID WP_004178461.1
Coordinates 4630880..4631413 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OM094_RS22670 Protein ID WP_002887278.1
Coordinates 4631424..4631690 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM094_RS22660 (4629711) 4629711..4630832 + 1122 WP_004214138.1 cupin domain-containing protein -
OM094_RS22665 (4630880) 4630880..4631413 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
OM094_RS22670 (4631424) 4631424..4631690 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OM094_RS22675 (4631793) 4631793..4633226 - 1434 WP_032418099.1 Cu(+)/Ag(+) sensor histidine kinase -
OM094_RS22680 (4633216) 4633216..4633899 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
OM094_RS22685 (4634071) 4634071..4635456 + 1386 WP_032418101.1 efflux transporter outer membrane subunit -
OM094_RS22690 (4635474) 4635474..4635818 + 345 WP_032418103.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T263741 WP_004178461.1 NZ_CP110369:c4631413-4630880 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT263741 WP_002887278.1 NZ_CP110369:c4631690-4631424 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References