Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2579761..2581349 Replicon chromosome
Accession NZ_CP110369
Organism Klebsiella pneumoniae isolate KP7626

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OM094_RS12705 Protein ID WP_004184027.1
Coordinates 2579761..2581083 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OM094_RS12710 Protein ID WP_004176198.1
Coordinates 2581083..2581349 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM094_RS12690 (2574817) 2574817..2577318 + 2502 WP_032439971.1 fimbria/pilus outer membrane usher protein -
OM094_RS12695 (2577306) 2577306..2578310 + 1005 WP_016946380.1 fimbrial protein -
OM094_RS12700 (2578452) 2578452..2579744 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OM094_RS12705 (2579761) 2579761..2581083 - 1323 WP_004184027.1 type II toxin-antitoxin system HipA family toxin Toxin
OM094_RS12710 (2581083) 2581083..2581349 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OM094_RS12715 (2581615) 2581615..2581941 - 327 WP_004215084.1 hydroxyisourate hydrolase -
OM094_RS12720 (2581938) 2581938..2582438 - 501 WP_032418978.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OM094_RS12725 (2582416) 2582416..2583795 - 1380 WP_265083995.1 nucleobase:cation symporter-2 family protein -
OM094_RS12730 (2584141) 2584141..2585295 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OM094_RS12735 (2585276) 2585276..2586199 - 924 WP_032418980.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T263738 WP_004184027.1 NZ_CP110369:c2581083-2579761 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT263738 WP_004176198.1 NZ_CP110369:c2581349-2581083 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References