Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1772728..1773318 Replicon chromosome
Accession NZ_CP110369
Organism Klebsiella pneumoniae isolate KP7626

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag OM094_RS08620 Protein ID WP_023341911.1
Coordinates 1772986..1773318 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag OM094_RS08615 Protein ID WP_000288812.1
Coordinates 1772728..1772985 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM094_RS08590 (1768638) 1768638..1768712 + 75 Protein_1682 type II toxin-antitoxin system PemK/MazF family toxin -
OM094_RS08595 (1769063) 1769063..1770811 + 1749 WP_032418698.1 hypothetical protein -
OM094_RS08600 (1770865) 1770865..1771446 + 582 WP_099184326.1 hypothetical protein -
OM094_RS08605 (1771729) 1771729..1772190 + 462 WP_004213450.1 hypothetical protein -
OM094_RS08610 (1772187) 1772187..1772393 + 207 WP_020805021.1 helix-turn-helix transcriptional regulator -
OM094_RS08615 (1772728) 1772728..1772985 + 258 WP_000288812.1 antitoxin Antitoxin
OM094_RS08620 (1772986) 1772986..1773318 + 333 WP_023341911.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OM094_RS08630 (1773640) 1773640..1775076 + 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
OM094_RS08640 (1775442) 1775442..1776896 - 1455 WP_004148975.1 AMP nucleosidase -
OM094_RS08645 (1777026) 1777026..1777271 - 246 WP_004141189.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11927.87 Da        Isoelectric Point: 10.4722

>T263733 WP_023341911.1 NZ_CP110369:1772986-1773318 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT263733 WP_000288812.1 NZ_CP110369:1772728-1772985 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References