Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 780638..781295 Replicon chromosome
Accession NZ_CP110369
Organism Klebsiella pneumoniae isolate KP7626

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OM094_RS03875 Protein ID WP_002916310.1
Coordinates 780885..781295 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OM094_RS03870 Protein ID WP_002916312.1
Coordinates 780638..780904 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM094_RS03845 (775794) 775794..777227 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
OM094_RS03850 (777346) 777346..778074 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OM094_RS03855 (778124) 778124..778435 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
OM094_RS03860 (778599) 778599..779258 + 660 WP_002916317.1 hemolysin III family protein -
OM094_RS03865 (779409) 779409..780392 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OM094_RS03870 (780638) 780638..780904 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OM094_RS03875 (780885) 780885..781295 + 411 WP_002916310.1 protein YgfX Toxin
OM094_RS03880 (781302) 781302..781823 - 522 WP_004144730.1 flavodoxin FldB -
OM094_RS03885 (781924) 781924..782820 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OM094_RS03890 (782843) 782843..783556 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OM094_RS03895 (783562) 783562..785295 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T263732 WP_002916310.1 NZ_CP110369:780885-781295 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT263732 WP_002916312.1 NZ_CP110369:780638-780904 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References