263730

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1317818..1318734 Replicon chromosome
Accession NZ_CP110365
Organism Bacillus subtilis strain HY2-62

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag LFL98_RS06960 Protein ID WP_277737090.1
Coordinates 1317988..1318734 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag LFL98_RS06955 Protein ID WP_003232646.1
Coordinates 1317818..1317988 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFL98_RS06920 (LFL98_06925) 1314681..1315010 + 330 WP_003232660.1 XkdW family protein -
LFL98_RS06925 (LFL98_06930) 1315007..1315171 + 165 WP_015715740.1 XkdX family protein -
LFL98_RS06930 (LFL98_06935) 1315215..1316054 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
LFL98_RS06935 (LFL98_06940) 1316107..1316376 + 270 WP_003232655.1 hemolysin XhlA family protein -
LFL98_RS06940 (LFL98_06945) 1316389..1316652 + 264 WP_003232653.1 phage holin -
LFL98_RS06945 (LFL98_06950) 1316665..1317558 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
LFL98_RS06950 (LFL98_06955) 1317595..1317732 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
LFL98_RS06955 (LFL98_06960) 1317818..1317988 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
LFL98_RS06960 (LFL98_06965) 1317988..1318734 - 747 WP_277737090.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
LFL98_RS06965 (LFL98_06970) 1318844..1319845 - 1002 WP_003232642.1 inorganic phosphate transporter -
LFL98_RS06970 (LFL98_06975) 1319858..1320475 - 618 WP_003218470.1 DUF47 domain-containing protein -
LFL98_RS06975 (LFL98_06980) 1320751..1322067 - 1317 WP_003244819.1 serine/threonine exchanger -
LFL98_RS06980 (LFL98_06985) 1322456..1323406 + 951 WP_003245086.1 ring-cleaving dioxygenase -
LFL98_RS06985 (LFL98_06990) 1323507..1323653 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29153.66 Da        Isoelectric Point: 4.6191

>T263730 WP_277737090.1 NZ_CP110365:c1318734-1317988 [Bacillus subtilis]
MVLFFQIMVWCIMAGLGLYVYATWRFEAKVKEKMFAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT263730 WP_003232646.1 NZ_CP110365:c1317988-1317818 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References