Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 933241..933807 Replicon chromosome
Accession NC_017218
Organism Bifidobacterium breve ACS-071-V-Sch8b

Toxin (Protein)


Gene name relE Uniprot ID S2ZEY8
Locus tag HMPREF9228_RS03810 Protein ID WP_014483710.1
Coordinates 933241..933534 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag HMPREF9228_RS03815 Protein ID WP_014483711.1
Coordinates 933538..933807 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF9228_RS10855 929347..929775 + 429 WP_003831803.1 hypothetical protein -
HMPREF9228_RS03790 929841..930194 - 354 WP_014483707.1 DUF488 domain-containing protein -
HMPREF9228_RS03795 930491..930730 + 240 WP_014483708.1 hypothetical protein -
HMPREF9228_RS03800 930972..932549 - 1578 WP_014483709.1 amino acid permease -
HMPREF9228_RS03805 932836..933132 - 297 WP_041473342.1 transporter -
HMPREF9228_RS03810 933241..933534 - 294 WP_014483710.1 type II toxin-antitoxin system YafQ family toxin Toxin
HMPREF9228_RS03815 933538..933807 - 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HMPREF9228_RS03820 933992..935160 - 1169 Protein_752 ABC transporter permease -
HMPREF9228_RS03825 935157..935837 - 681 WP_014483712.1 ABC transporter ATP-binding protein -
HMPREF9228_RS03830 935834..936724 - 891 WP_014483713.1 hypothetical protein -
HMPREF9228_RS03835 936721..937236 - 516 WP_013140733.1 hypothetical protein -
HMPREF9228_RS03840 937362..938057 + 696 WP_003829410.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 933241..943340 10099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.96 Da        Isoelectric Point: 9.7881

>T26373 WP_014483710.1 NC_017218:c933534-933241 [Bifidobacterium breve ACS-071-V-Sch8b]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T26373 NC_017218:c933534-933241 [Bifidobacterium breve ACS-071-V-Sch8b]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT26373 WP_014483711.1 NC_017218:c933807-933538 [Bifidobacterium breve ACS-071-V-Sch8b]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT26373 NC_017218:c933807-933538 [Bifidobacterium breve ACS-071-V-Sch8b]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCCCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S2ZEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References