Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4899664..4901237 Replicon chromosome
Accession NZ_CP110364
Organism Aeromonas veronii strain C4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ONR73_RS23220 Protein ID WP_265061840.1
Coordinates 4899664..4900983 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ONR73_RS23225 Protein ID WP_017410478.1
Coordinates 4900983..4901237 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONR73_RS23205 (ONR73_23205) 4895580..4896344 + 765 WP_124930500.1 ATP-binding cassette domain-containing protein -
ONR73_RS23210 (ONR73_23210) 4896379..4897263 + 885 WP_265062953.1 ABC transporter substrate-binding protein -
ONR73_RS23215 (ONR73_23215) 4897260..4899242 + 1983 WP_265061839.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
ONR73_RS23220 (ONR73_23220) 4899664..4900983 - 1320 WP_265061840.1 type II toxin-antitoxin system HipA family toxin Toxin
ONR73_RS23225 (ONR73_23225) 4900983..4901237 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
ONR73_RS23230 (ONR73_23230) 4901557..4902051 + 495 WP_136501637.1 permease -
ONR73_RS23235 (ONR73_23235) 4902091..4903215 + 1125 WP_151286438.1 HlyD family secretion protein -
ONR73_RS23240 (ONR73_23240) 4903205..4904236 + 1032 WP_265061841.1 DUF2955 domain-containing protein -
ONR73_RS23245 (ONR73_23245) 4904685..4905113 - 429 WP_245133371.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49543.58 Da        Isoelectric Point: 6.6626

>T263728 WP_265061840.1 NZ_CP110364:c4900983-4899664 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYIDGRWYLPLKATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSIFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKTVGFERSAMEEILTELANSV
DDVIELVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT263728 WP_017410478.1 NZ_CP110364:c4901237-4900983 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References