Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2200246..2201831 Replicon chromosome
Accession NZ_CP110362
Organism Dickeya dadantii strain XJ12

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OL445_RS09895 Protein ID WP_077246342.1
Coordinates 2200512..2201831 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OL445_RS09890 Protein ID WP_033112453.1
Coordinates 2200246..2200512 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OL445_RS09865 2195544..2196155 - 612 WP_077246347.1 NAD(P)-dependent oxidoreductase -
OL445_RS09870 2196298..2196678 + 381 WP_038902818.1 helix-turn-helix domain-containing protein -
OL445_RS09875 2196803..2197888 - 1086 WP_284603684.1 4-hydroxyphenylpyruvate dioxygenase -
OL445_RS09880 2198203..2198976 + 774 WP_033112166.1 MBL fold metallo-hydrolase -
OL445_RS09885 2199019..2199996 + 978 WP_013320107.1 helix-turn-helix domain-containing protein -
OL445_RS09890 2200246..2200512 + 267 WP_033112453.1 helix-turn-helix domain-containing protein Antitoxin
OL445_RS09895 2200512..2201831 + 1320 WP_077246342.1 type II toxin-antitoxin system HipA family toxin Toxin
OL445_RS09900 2202280..2205429 - 3150 WP_284603686.1 type I restriction endonuclease subunit R -
OL445_RS09905 2205426..2206448 - 1023 WP_284603687.1 SIR2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49414.50 Da        Isoelectric Point: 7.3303

>T263716 WP_077246342.1 NZ_CP110362:2200512-2201831 [Dickeya dadantii]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGNRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGIPARDIKQIEYKTLSEQQLESILSGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIARAFGLPVPHCFMIKAGKIKALAVERFDRK
YASDGSWIMRLPQEDFCQVLNVPSALKYENHGGPGISDIMSYLLGAVDPQRDRYSFMKAQVLFWLLAATDGHAKNFSLFI
ESQGRYRLTPYYDILSMYPAFGGRGIDRRDAKLAMGLAGTRGKKYHIEQIFPRHFFQTAKAVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSRRLTTGWE

Download         Length: 1320 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9883.23 Da        Isoelectric Point: 9.7281

>AT263716 WP_033112453.1 NZ_CP110362:2200246-2200512 [Dickeya dadantii]
MKVTNAKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNMDAANNEASV
APSWKEEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References