Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 479813..480384 Replicon chromosome
Accession NZ_CP110360
Organism Enterococcus faecium strain AKSZ-142

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MZO31_RS03560 Protein ID WP_002327666.1
Coordinates 480043..480384 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag MZO31_RS03555 Protein ID WP_002323011.1
Coordinates 479813..480043 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZO31_RS03530 (MZO31_03525) 475051..476379 + 1329 WP_002327663.1 FAD-containing oxidoreductase -
MZO31_RS03535 (MZO31_03530) 476401..477027 + 627 WP_151669150.1 cysteine hydrolase -
MZO31_RS03540 (MZO31_03535) 477210..477791 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
MZO31_RS03545 (MZO31_03540) 478403..478978 + 576 WP_002327664.1 SOS response-associated peptidase family protein -
MZO31_RS03550 (MZO31_03545) 479179..479517 - 339 WP_002327665.1 hypothetical protein -
MZO31_RS03555 (MZO31_03550) 479813..480043 + 231 WP_002323011.1 hypothetical protein Antitoxin
MZO31_RS03560 (MZO31_03555) 480043..480384 + 342 WP_002327666.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MZO31_RS03570 (MZO31_03565) 482437..482580 + 144 Protein_452 class C sortase -
MZO31_RS03575 (MZO31_03570) 482761..483435 + 675 WP_002327673.1 response regulator transcription factor -
MZO31_RS03580 (MZO31_03575) 483453..484478 + 1026 WP_002286770.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13264.67 Da        Isoelectric Point: 10.1461

>T263712 WP_002327666.1 NZ_CP110360:480043-480384 [Enterococcus faecium]
VSGERIYIPKKGDIVWIYFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIISQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT263712 WP_002323011.1 NZ_CP110360:479813-480043 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References