Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 189644..190173 Replicon chromosome
Accession NZ_CP110360
Organism Enterococcus faecium strain AKSZ-142

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag MZO31_RS02240 Protein ID WP_002294198.1
Coordinates 189907..190173 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag MZO31_RS02235 Protein ID WP_002294199.1
Coordinates 189644..189907 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZO31_RS02220 (MZO31_02220) 186054..187499 + 1446 WP_219282475.1 alpha-N-arabinofuranosidase -
MZO31_RS02225 (MZO31_02225) 187504..187770 + 267 WP_002315578.1 DUF6171 family protein -
MZO31_RS02230 (MZO31_02230) 187823..189013 + 1191 WP_098188873.1 arabinan endo-1,5-alpha-L-arabinosidase -
MZO31_RS02235 (MZO31_02235) 189644..189907 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MZO31_RS02240 (MZO31_02240) 189907..190173 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
MZO31_RS02245 (MZO31_02245) 190374..190862 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
MZO31_RS02250 (MZO31_02250) 191404..192057 - 654 WP_002317081.1 ABC transporter permease -
MZO31_RS02255 (MZO31_02255) 192072..192989 - 918 WP_002298332.1 osmoprotectant ABC transporter substrate-binding protein -
MZO31_RS02260 (MZO31_02260) 192986..193627 - 642 WP_002293405.1 ABC transporter permease -
MZO31_RS02265 (MZO31_02265) 193631..194806 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T263711 WP_002294198.1 NZ_CP110360:189907-190173 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT263711 WP_002294199.1 NZ_CP110360:189644-189907 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References