Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4806103..4806719 Replicon chromosome
Accession NZ_CP110354
Organism Enterobacter hormaechei strain ECC2783

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OLI86_RS23285 Protein ID WP_015569913.1
Coordinates 4806103..4806474 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag OLI86_RS23290 Protein ID WP_015569912.1
Coordinates 4806477..4806719 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLI86_RS23270 (OLI86_23270) 4803603..4804505 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
OLI86_RS23275 (OLI86_23275) 4804502..4805137 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
OLI86_RS23280 (OLI86_23280) 4805134..4806063 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
OLI86_RS23285 (OLI86_23285) 4806103..4806474 - 372 WP_015569913.1 PIN domain-containing protein Toxin
OLI86_RS23290 (OLI86_23290) 4806477..4806719 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
OLI86_RS23295 (OLI86_23295) 4806918..4807838 + 921 WP_015569911.1 alpha/beta hydrolase -
OLI86_RS23300 (OLI86_23300) 4807847..4808788 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
OLI86_RS23305 (OLI86_23305) 4808833..4809270 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
OLI86_RS23310 (OLI86_23310) 4809267..4810148 - 882 WP_003861949.1 virulence factor BrkB family protein -
OLI86_RS23315 (OLI86_23315) 4810142..4810741 - 600 WP_003861947.1 glucose-1-phosphatase -
OLI86_RS23320 (OLI86_23320) 4810860..4811660 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T263707 WP_015569913.1 NZ_CP110354:c4806474-4806103 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT263707 WP_015569912.1 NZ_CP110354:c4806719-4806477 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References