Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3866467..3867124 Replicon chromosome
Accession NZ_CP110354
Organism Enterobacter hormaechei strain ECC2783

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag OLI86_RS18740 Protein ID WP_017382887.1
Coordinates 3866467..3866877 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag OLI86_RS18745 Protein ID WP_003863437.1
Coordinates 3866858..3867124 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLI86_RS18720 (OLI86_18720) 3862465..3864198 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
OLI86_RS18725 (OLI86_18725) 3864204..3864917 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OLI86_RS18730 (OLI86_18730) 3864946..3865842 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
OLI86_RS18735 (OLI86_18735) 3865944..3866465 + 522 WP_015571793.1 flavodoxin FldB -
OLI86_RS18740 (OLI86_18740) 3866467..3866877 - 411 WP_017382887.1 protein YgfX Toxin
OLI86_RS18745 (OLI86_18745) 3866858..3867124 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
OLI86_RS18750 (OLI86_18750) 3867419..3868399 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
OLI86_RS18755 (OLI86_18755) 3868511..3869170 - 660 WP_003863433.1 hemolysin III family protein -
OLI86_RS18760 (OLI86_18760) 3869437..3870168 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
OLI86_RS18765 (OLI86_18765) 3870285..3871718 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T263706 WP_017382887.1 NZ_CP110354:c3866877-3866467 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT263706 WP_003863437.1 NZ_CP110354:c3867124-3866858 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References