Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2370688..2371427 Replicon chromosome
Accession NZ_CP110354
Organism Enterobacter hormaechei strain ECC2783

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag OLI86_RS11445 Protein ID WP_017382345.1
Coordinates 2370688..2371173 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag OLI86_RS11450 Protein ID WP_003857131.1
Coordinates 2371161..2371427 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLI86_RS11430 (OLI86_11430) 2366342..2369359 + 3018 WP_004199413.1 Tn3-like element IS3000 family transposase -
OLI86_RS11435 (OLI86_11435) 2369402..2369704 + 303 WP_265027367.1 hypothetical protein -
OLI86_RS11440 (OLI86_11440) 2370068..2370637 + 570 WP_017382346.1 hypothetical protein -
OLI86_RS11445 (OLI86_11445) 2370688..2371173 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
OLI86_RS11450 (OLI86_11450) 2371161..2371427 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
OLI86_RS11455 (OLI86_11455) 2371491..2372420 - 930 WP_023303744.1 LysR family transcriptional regulator -
OLI86_RS11460 (OLI86_11460) 2372550..2373938 + 1389 WP_032619651.1 MFS transporter -
OLI86_RS11465 (OLI86_11465) 2373960..2374955 - 996 WP_023303746.1 DUF2891 domain-containing protein -
OLI86_RS11470 (OLI86_11470) 2374965..2375951 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2366342..2369359 3017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T263699 WP_017382345.1 NZ_CP110354:c2371173-2370688 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT263699 WP_003857131.1 NZ_CP110354:c2371427-2371161 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References