Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1107707..1108327 Replicon chromosome
Accession NZ_CP110354
Organism Enterobacter hormaechei strain ECC2783

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag OLI86_RS05290 Protein ID WP_015571250.1
Coordinates 1107707..1107925 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag OLI86_RS05295 Protein ID WP_006809850.1
Coordinates 1107953..1108327 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLI86_RS05260 (OLI86_05260) 1103719..1103979 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
OLI86_RS05265 (OLI86_05265) 1103982..1104122 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OLI86_RS05270 (OLI86_05270) 1104119..1104829 - 711 WP_023303201.1 GNAT family protein -
OLI86_RS05275 (OLI86_05275) 1104931..1106391 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
OLI86_RS05280 (OLI86_05280) 1106363..1106830 - 468 WP_017383209.1 YlaC family protein -
OLI86_RS05285 (OLI86_05285) 1106947..1107498 - 552 WP_023303203.1 maltose O-acetyltransferase -
OLI86_RS05290 (OLI86_05290) 1107707..1107925 - 219 WP_015571250.1 HHA domain-containing protein Toxin
OLI86_RS05295 (OLI86_05295) 1107953..1108327 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
OLI86_RS05300 (OLI86_05300) 1108838..1111984 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
OLI86_RS05305 (OLI86_05305) 1112007..1113200 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T263698 WP_015571250.1 NZ_CP110354:c1107925-1107707 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT263698 WP_006809850.1 NZ_CP110354:c1108327-1107953 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References