Detailed information of TA system TA263692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1942625..1944133
• Replicon: chromosome
• Accession: NZ_CP110353
• Organism: Pseudomonas aeruginosa strain PALA48

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PALA48_RS09375
• Protein ID: WP_012613851.1
• Coordinates: 1942625..1943212 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PALA48_RS09380
• Protein ID: WP_012613852.1
• Coordinates: 1943279..1944133 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PALA48_RS09370 (PALA48_01858)	1938880..1942359	-	3480	WP_003117605.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
PALA48_RS09375 (PALA48_01859)	1942625..1943212	+	588	WP_012613851.1	GNAT family protein	Toxin
PALA48_RS09380 (PALA48_01860)	1943279..1944133	+	855	WP_012613852.1	AraC family transcriptional regulator	Antitoxin
PALA48_RS09385 (PALA48_01861)	1944230..1946395	+	2166	WP_003091606.1	TonB-dependent receptor family protein	-
PALA48_RS09390 (PALA48_01862)	1946570..1948444	+	1875	WP_003158329.1	MFS transporter	-
PALA48_RS09395 (PALA48_01863)	1948505..1948714	-	210	WP_003115568.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T263692 WP_012613851.1 NZ_CP110353:1942625-1943212 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31959.27 Da
• Isoelectric Point: 7.3276

>AT263692 WP_012613852.1 NZ_CP110353:1943279-1944133 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp