Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4535901..4537159 Replicon chromosome
Accession NZ_CP110352
Organism Pseudomonas aeruginosa strain PALA47

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA47_RS20940 Protein ID WP_003112528.1
Coordinates 4535901..4536656 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA47_RS20945 Protein ID WP_003086329.1
Coordinates 4536791..4537159 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA47_RS20930 (PALA47_04149) 4531074..4533617 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
PALA47_RS20935 (PALA47_04150) 4533772..4535133 - 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA47_RS20940 (PALA47_04151) 4535901..4536656 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA47_RS20945 (PALA47_04152) 4536791..4537159 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA47_RS20950 (PALA47_04153) 4537232..4538518 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
PALA47_RS20955 (PALA47_04154) 4538574..4540163 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA47_RS20960 (PALA47_04155) 4540242..4540718 + 477 WP_003112531.1 hypothetical protein -
PALA47_RS20965 4540721..4540996 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T263687 WP_003112528.1 NZ_CP110352:c4536656-4535901 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT263687 WP_003086329.1 NZ_CP110352:c4537159-4536791 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References