Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1571991..1573249 Replicon chromosome
Accession NZ_CP110351
Organism Pseudomonas aeruginosa strain PALA45

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA45_RS07395 Protein ID WP_012614407.1
Coordinates 1572494..1573249 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA45_RS07390 Protein ID WP_003086329.1
Coordinates 1571991..1572359 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA45_RS07370 1568154..1568429 + 276 WP_169057979.1 zinc ribbon domain-containing protein -
PALA45_RS07375 (PALA45_01457) 1568432..1568908 - 477 WP_003112531.1 hypothetical protein -
PALA45_RS07380 (PALA45_01458) 1568987..1570576 + 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA45_RS07385 (PALA45_01459) 1570632..1571918 + 1287 WP_012614408.1 FAD-binding oxidoreductase -
PALA45_RS07390 (PALA45_01460) 1571991..1572359 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA45_RS07395 (PALA45_01461) 1572494..1573249 + 756 WP_012614407.1 RES family NAD+ phosphorylase Toxin
PALA45_RS07400 (PALA45_01462) 1574017..1575378 + 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA45_RS07405 (PALA45_01463) 1575533..1578076 - 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T263679 WP_012614407.1 NZ_CP110351:1572494-1573249 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT263679 WP_003086329.1 NZ_CP110351:1571991-1572359 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References