Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141945..142450 Replicon chromosome
Accession NZ_CP110351
Organism Pseudomonas aeruginosa strain PALA45

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA45_RS00650 Protein ID WP_003083773.1
Coordinates 141945..142226 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA45_RS00655 Protein ID WP_003083775.1
Coordinates 142223..142450 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA45_RS00625 (PALA45_00124) 137196..138545 + 1350 WP_012613447.1 C4-dicarboxylate transporter DctA -
PALA45_RS00630 (PALA45_00125) 138594..139280 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA45_RS00635 (PALA45_00126) 139381..140115 + 735 WP_003117208.1 GntR family transcriptional regulator -
PALA45_RS00640 (PALA45_00127) 140295..140705 + 411 WP_003101225.1 aegerolysin family protein -
PALA45_RS00645 (PALA45_00128) 140737..141645 - 909 WP_012613448.1 LysR family transcriptional regulator -
PALA45_RS00650 (PALA45_00129) 141945..142226 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA45_RS00655 (PALA45_00130) 142223..142450 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA45_RS00660 (PALA45_00131) 142626..143246 - 621 WP_003101226.1 hypothetical protein -
PALA45_RS00665 (PALA45_00132) 143347..143847 + 501 WP_003101228.1 LEA type 2 family protein -
PALA45_RS00670 (PALA45_00133) 143920..144261 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA45_RS00675 (PALA45_00134) 144343..145770 - 1428 WP_003083784.1 GABA permease -
PALA45_RS00680 (PALA45_00135) 145939..147432 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T263677 WP_003083773.1 NZ_CP110351:c142226-141945 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT263677 WP_003083775.1 NZ_CP110351:c142450-142223 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References