Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5931620..5932878 Replicon chromosome
Accession NZ_CP110350
Organism Pseudomonas aeruginosa strain PALA44

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PALA44_RS27760 Protein ID WP_003086331.1
Coordinates 5931620..5932375 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA44_RS27765 Protein ID WP_003086329.1
Coordinates 5932510..5932878 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA44_RS27750 (PALA44_05483) 5926791..5929334 + 2544 WP_034005179.1 acyl-homoserine-lactone acylase QuiP -
PALA44_RS27755 (PALA44_05484) 5929489..5930850 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA44_RS27760 (PALA44_05485) 5931620..5932375 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PALA44_RS27765 (PALA44_05486) 5932510..5932878 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA44_RS27770 (PALA44_05487) 5932951..5934237 - 1287 WP_033939236.1 FAD-binding oxidoreductase -
PALA44_RS27775 (PALA44_05488) 5934293..5935882 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA44_RS27780 (PALA44_05489) 5935961..5936437 + 477 WP_003140638.1 hypothetical protein -
PALA44_RS27785 (PALA44_05490) 5936440..5936715 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T263676 WP_003086331.1 NZ_CP110350:c5932375-5931620 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT263676 WP_003086329.1 NZ_CP110350:c5932878-5932510 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References